Libro: Advanced Pharmacokinetics and Pharmacodynamics: Lecture Notes and Self-study Guide

I wrote this book based on a 3-credit hour graduate course, "Advanced Pharmacokinetics and Pharmacodynamics", that I have been teaching in the past 10 years. The content of my course was based on my two-decade-long PK/PD research experience plus knowledge learned from multiple PK/PD courses from SUNY, University at Buffalo, whose PK/PD program has been #1 in the world for several decades. If you want to be a pharmacometrician and/or become a modeling expert, this book is for you.

The first half of the book (Chapters 1-7) teaches the fundamentals, including how to draw model diagrams, how to write PK differential equations, and how to solve them using Laplace transformation.

The second half of the book (Chapters 8-16) covers more advanced topics, including various PK models (e.g., nonlinear PK, TMDD model, whole-body PBPK, PopPK), PD models (e.g., effect compartment, indirect response models) and QSP models (e.g., platform QSP models for new drug modalities).

Appendix 1 shares the scientific journey of a legend in PK/PD- interview with Dr. William Jusko.

In addition, I included the history of many important models in this book so that readers could get a big picture of the PK/PD discipline and have a deeper understanding of “where we came from” and “where we are now”.

Note: This book targets advanced users and is not suitable for beginners who just stepped into the PK/PD world. For beginners, please consider reading my basic PK textbook ("Essentials in Clinical Pharmacokinetics: Concepts, Dose Optimization, and Biologics", which is also available at Amazon) to build a solid foundation first before reading this book.

My website (An PKPD Lab): https://an.lab.uiowa.edu/
All my books: https://www.amazon.com/author/guohua-an

If you are interested in my future book(s), please follow/connect me at LinkedIn (https://www.linkedin.com/in/guohua-an/), which is the main platform I use for posting, including book announcement.

Additional Note: I did not use AI in my writing. Except for Appendix 1, which is an interview, I wrote the whole book, word by word. In the age of AI, I consider this 100% human written book special. I hope readers enjoy my writing and find this book useful.